Select prior publications
Kovach AE, Ding YY, Lamble AJ, Bernt K, Bomken S, Brodersen LE, Buldini B, Delgado Colon D, Coorens THH, Green Gladden R, Gu Z, Hu S, Jacoby E, Janssens D, Kurzer JH, Mejstrikova E, Raikar SS, Rheingold SR, Silbert SK, Tan K, Yuan C, Wang HW, Ghorashian S, Shah NN, Davis KL. Plasticity Under Pressure: The Biology and Detection of Lineage Switch in Acute Leukemia. Leukemia, in press
Chen CC; Xu J, Vincent T, Tumulty JS; Yoshimura S; Alikarami F; Yu W; Ding YY; Chen CH; Li EY; Chen C, Xu J, Sussman JH, Vincent TL, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng JJ, Pölönen P, Newman H, Wood B, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K. Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood. 2025 Mar 16. PMID: 40089994
Ding YY, Sussman S, Yu W, Mathier B, Madden K, Xu J, Chen C, Johnson A, Chen CH, He B, Hottman D, Chen R, Falkenstein C, Loftus JP, Zhang Z, Bandyopadhyay S, Dang C, Lee DG, Wang H, Peng J, Tasian SK, Tan K. Targeting Senescent Stem-Like Subpopulations in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia. Blood. 2025 Jan 7;blood.2024026482.
Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT. A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer. 2024 Nov 25. doi: 10.1038/s43018-024-00863-5. PMID: 39587259.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K. Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. 2022 Apr 7;139(14):2198–2211. PMCID: PMC8990373
Ding YY, Kim H, Madden K, Loftus JP, Chen GM, Hottman Allen D, Zhang R, Xu J, Chen C-H, Hu Y, Tasian SK, Tan K. Network Analysis Reveals Rational Combination Therapy Targets in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia. Clin Cancer Res. 2021 Jul 1. PMCID: PMC8448976.
Hu Y, Chen C, Ding YY, Wen X, Wang B, Gao L, Tan K. Optimal control nodes in disease-perturbed networks as targets for combination therapy. Nat Commun. 2019. PMCID: PMC6522545.
He B, Gao P, Ding YY, Chen C, Chen GM, Chen C, Kim H, Tasian SK, Hunger SP, Tan K. Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. Science Advances. 2020 Jul 24;6(30). PMCID: PMC7439310.
Ding YY, Stern JW, Jubelirer TF, Wertheim GB, Li F, Chang F, Gu Z, Mullighan CG, Li Y, Harvey RC, Chen IM, Willman CL, Hunger SP, Li MM, and Tasian SK. Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure. Haematologica. 2018. 103(9):e427-e431. PMCID: PMC6119161.
Chen GM, Chen C, Das RK, Gao P, Chen CH, Bandyopadhyay S, Ding YY, Uzun Y, Yu W, Zhu Q, Myers RM, Grupp SA, Barrett DM, Tan K. Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy. Cancer Discov 2021;11:2186–99. PMCID: PMC8419030.
Chen GM, Azzam A, Ding YY, Barrett DM, Grupp SA, Tan K. Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach. Clin Cancer Res 2020;26:3505–13. PMCID: PMC7367708.
